How interesting 606, I’d never really given this too much thought before? Although I recall a story I heard about Batistuta wetting the bed because he was unable to go through the pain of walking to the toilet. It states in the links below that it was so bad he actually asked a doctor to amputate both his legs above the ankle? I would assume this was one of the possible consequences of painkiller/drug overuse?https://en.wikipedia.org/wiki/Gabriel_Batistuta
http://www.worldsoccer.com/news/gabriel-batistuta-asked-legs-amputated-356207